PERSONAL DE APOYO
ELESGARAY Rosana
artículos
Título:
Morphological and functional effects on cardiac tissue induced by moderate zinc deficiency during prenatal and postnatal life in male and female rats.
Autor/es:
TOMAT ANALÍA; JURIOL LORENA; GOBETTO NATALIA; VEIRAS LUCIANA; MENDES GARRIDO FACUNDO; JUDITH ZILBERMAN; FASOLI HÉCTOR; ELESGARAY ROSANA; COSTA MARÍA ÁNGELES; ARRANZ CRISTINA
Revista:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Editorial:
AMER PHYSIOLOGICAL SOC
Referencias:
Lugar: Bethesda; Año: 2013 p. 1574 - 1583
ISSN:
0363-6135
Resumen:
The aim of this study was to evaluate whether moderate zinc restriction in rats
throughout fetal life, lactation, and/or postweaning growth results in early
changes in cardiac morphology predisposing the onset of cardiac dysfunction
in adult life as well as sex-related differences in the adaptation
to this nutritional injury. Female Wistar rats received low or control zinc
diets from the beginning of pregnancy up to offspring weaning. After
being weaned, offspring were fed either a low or control zinc diet until 81
days. Systolic blood pressure was measured. Echocardiographic and
electrocardiographic examinations, morphological experiments, and apoptosis
by TUNEL assay were performed in the left ventricle. In the early
stages, zinc-deficient male and female offspring showed an increase in
cardiomyocyte diameter, probably associated with an increase in cardiac
apoptotic cells, but smaller myocyte diameters in adulthood. In adult
males, this nutritional injury induced decreased contractility and dilatation
of the left ventricle, not allowing the heart to compensate the higher
levels of blood pressure, and hypertrophic remodeling of coronary arteries
associated with increased blood pressure. Adequate zinc intake during
postweaning life did not overcome blood pressure levels but reversed
some of the detrimental effects of earlier zinc deficiency in cardiac
morphology and function. Females were less sensitive to this deficiency,
exhibiting normal levels of blood pressure and no structural or functional
heart alterations in adult life. The present study demonstrates that the
effects of zinc deficiency on blood pressure, cardiac morphology, and
function differ between sexes, with males more predisposed to develop
cardiovascular diseases in adulthood.