PERSONAL DE APOYO
ELESGARAY Rosana
artículos
Título:
Mild zinc deficiency in male and female rats: early postnatal alterations in renal nitric oxide system and morphology.
Autor/es:
TOMAT ANALÍA; VEIRAS LUCIANA; AGUIRRE SOFÍA; FASOLI HÉCTOR; ELESGARAY ROSANA; CANIFFI CAROLINA; COSTA MARÍA ÁNGELES; ARRANZ CRISTINA
Revista:
NUTRITION
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 29 p. 568 - 573
ISSN:
0899-9007
Resumen:
OBJECTIVE:
Fetal and postnatal zinc deficiencies induce an
increase in arterial blood pressure and impair renal function in male
adult rats. We therefore hypothesized that these renal alterations are
present in early stages of life and that there are sexual differences in
the adaptations to this nutritional injury. The aim was to study the
effects of moderate zinc deficiency during fetal life and lactation on
renal morphology, oxidative stress, apoptosis, and the nitric oxide
system in male and female rats at 21 d of life.
METHODS:
Female
Wistar rats received low (8 ppm) or control (30 ppm) zinc diets from
the beginning of pregnancy to weaning. Glomerulus number, morphology,
oxidative stress, apoptotic cells, nitric oxide synthase activity, and
protein expression were evaluated in the kidneys of offspring at 21 d.
RESULTS:
Zinc
deficiency decreased the nephron number, induced glomerular
hypertrophy, increased oxidative damage, and decreased nitric oxide
synthase activity in the male and female rat kidneys. Nitric oxide
synthase activity was not affected by inhibitors of the neuronal or
inducible isoforms, so nitric oxide was mainly generated by the
endothelial isoenzyme. Gender differences were observed in glomerular
areas and antioxidant enzyme activities.
CONCLUSION:
Zinc
deficiency during fetal life and lactation induces an early decrease in
renal functional units, associated with a decrease in nitric oxide
activity and an increase in oxidative stress, which would contribute to
increased arterial blood pressure and renal dysfunction in adulthood.
The sexual differences observed in this model may explain the dissimilar
development of hypertension and renal diseases in adult life.