PERSONAL DE APOYO
PAULAZO Maria Alejandra
congresos y reuniones científicas
Título:
THE THYROID STATUS REGULATES TRIPLE NEGATIVE BREAST CANCER (TNBC) GROWTH AND METASTASIS THROUGH THE MODULATION OF MESENCHYMAL STROMAL CELL (MSC) MIGRATION AND ANTITUMOR IMMUNE RESPONSE
Autor/es:
STERLE, H.A.; HILDEBRANDT X.; GUTIERREZ L.; PAULAZO M.A.; CAYROL M.F.; DIAZ FLAQUÉ C.; ROSEMBLIT C.; BOLONTRADE M.; CREMASCHI G.A.
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión Conjunta SAIC SAI SAFIS 2018; 2018
Resumen:
The association between thyroid disease and breast cancer riskremains unclear. Our aim was to evaluate the effect of thyroidstatus on TNBC development. For this, Balb/c mice were orthotopicallyinoculated with 4T1 cells after the treatment with thyroxine(12mg/l) for 30 days or propylthiouracil (500mg/l) for 15 days in thedrinking water to obtain hyperthyroid (hyper) or hypothyroid (hypo)mice, respectively. An increased tumor growth rate, that becameevident at day 21 post-inoculation (p.i.), was seen in hyper micecompared to controls (p
