EVALUATING ZINC IMPORTANCE ON LYMPHOCYTE ACTIVITY IN HORMONE HYPOTHYROID CONDITIONS

KLECHA A.J.; PAULAZO M.A.; STERLE H.A.; DIAZ FLAQUÉ C.; CAYROL M.F.; BARREIRO ARCOS, M.L.; CREMASCHI G.A.

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Immunity is modulated by a complex net of immune and neuroendocrinefactors, among them, hypothyroidism leading to immunosuppression.Additionally, Zinc (Zn) is a trace element which deficitinduces a decrease in lymphocyte number and activity as well asadversely affects the synthesis, metabolism and action of thyroidhormones (TH). Our aim was to study if hypothyroid conditionsmay alter zinc metabolism and if this is related to the impairment inT lymphocyte activity.We evaluated the impact of hypothyroidism on Zn metabolismand its possible relationship with T cell activity. Hypothyroid miceshowed lower levels of zinc in femur and lymph nodes than controls.T3 reversion of the hypothyroid status, as well as Zn supplementationrevert these effects (p