THYROID HORMONES INDUCE CHEMOSENSITIVITY TO DOXORUBICIN IN JURKAT CELLS THROUGH THE MODULATION OF ENZYMES INVOLVED IN CHEMOTHERAPY DRUG METABOLISM

MARÍA CELESTE DÍAZ FLAQUÉ, ; MARÍA FLORENCIA CAYROL,; HELENA STERLE, ; CINTHIA ROSEMBLIT, ; ALEJANDRA PAULAZO, ; JOHANNA DÍAZ ALBUJA, ; ALICIA KLECHA, ; MARIA LAURA BARREIRO ARCOS, ; GRACIELA CREMASCHI

Buenos Aires

Congreso; Reunión Conjunta de sociedades de Biociencias; 2017

Sociedad Argentina de Investigación Clínica y 9 Sociedades Científicas más

Thyroid hormones (TH) ? 3,3´,5-triiodo-L-thyronine (T3) and L-thyroxine(T4) ? are important regulators of the metabolism and physiologyof most normal tissues. We recently showed that TH stimulatethe proliferation and metabolism of T cells.To assess the effect of TH on the response to conventional chemotherapy,we determined the Doxorubicin (DOX) dose that inhibits proliferation by 50% (IC50) in presence or absence of TH. As expected,DOX induces cytotoxicity in a dose-dependent manner in cellstreated or not with TH. It is important to note that under proliferativeconditions, pretreatment with TH sensitizes Jurkat cells to DOXtreatment. Noteworthy pretreatment with TH significantly decreaseschemosensitivity to DOX by 50% (p