Antioxidant action of Cannabis sativa resin and CBD and synergism induced by Larrea divaricata and Tilia x viridis extracts

SAINT MARTIN MALEN; IGNACIO PERALTA; FRESIA SILVA SOFRÁS; LAURA COGOI; CATALINA VAN BAREN; ALONSO MARÍA ROSARIO; ANESINI CLAUDIA

Mar del Plata

Otro; Reunión Anual SAIC ? SAFE ? SAB ? SAP 2019; 2019

SAIC ? SAFE ? SAB ? SAP

Cannabis sativa L. (Cannabaceae) is a medicinal plant used as anticonvulsant in refractory epilepsy in kids. Convulsions induce oxidative stress (OS) in cerebral tissues which affects the normal function of the central nervous system altering cognitive functioning. The synergistic effects of plants could not only improve therapeutic effects but also mitigate adverse effects. Larrea divaricata Cav. (Zygophylliaceae) is an autochthonous plant with a well documented antioxidant activity and Tilia viridis ssp x moltkei (Malvaceae) is a plant used for its anxiolytic effects. The purpose of this work was to evaluate the antioxidant activity of an ethanolic extract (EEC) of C. sativa, studying the participation of the cannabinoid CBD in its action and to evaluate for the first time the possible synergistic combination of EEC with aqueous extracts of L. divaricata (AEL) and Tilia x viridis (AET).