PERSONAL DE APOYO
ALONSO Maria Rosario
congresos y reuniones científicas
Título:
) INHIBITION OF LIPID PEROXIDATION BY CANNABIS SATIVA AND LARREA DIVARICATA EXTRACTS AND THEIR COMBINATION
Autor/es:
SAINT MARTIN MALEN; PERALTA IGNACIO; FRESIA SILVA SOFRÁS; COGOI LAURA; CATALINA VAN BAREN; ALONSO MARÍA ROSARIO; ANESINI CLAUDIA
Lugar:
CIUDAD DE BUENOS AIRES
Reunión:
Congreso; 53º Reunión Anual SAFE; 2021
Institución organizadora:
Sociedad Argentina de Farmacología experimental
Resumen:
Oxidative stress, through lipid peroxidation, affects central nervous system altering cognitive functioning during epilepsy. Cannabis sativa L. (Cannabaceae) is a medicinal plant used as anticonvulsant, being cannabidiol (CBD) its main anticonvulsant agent. Larrea divaricata Cav. (Zygophylliaceae) is an autochthonous plant with antioxidant activity. The aim of this work was to study the synergistic effect of an ethanolic extract of C. sativa (CSR) and an aqueous extractof L. divaricata (LE) on inhibition of lipid peroxidation to improve the therapeutic outcomes. The participation of CBD and nordihydroguaiaretic acid (NDGA) was evaluated.
