PERSONAL DE APOYO
ALONSO Maria Rosario
artículos
Título:
Validated HPLC method for cynarin determination in biological samples
Autor/es:
MARIA ROSARIO ALONSO; MARIA DEL CARMEN GARCIA,; CLAUDIA GARCIA BONELLI,; GRACIELA FERRARO; MODESTO RUBIO
Revista:
ACTA FARM. BONAERENSE
Editorial:
COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
Referencias:
Lugar: La Plata; Año: 2006 vol. 25 p. 267 - 270
ISSN:
0326-2383
Resumen:
SUMMARY. A simple and sensitive method for the determination of cynarin is described and partially
validated. The assay was used to determine the pharmacokinetic profile of cynarin after Wistar rat intravenous
administration. Cynarin was isolated from rat plasma by solid-phase extraction. Separations were
performed by reversed-phase high-performance liquid chromatography with ultraviolet detection
