Manitol influence on the less renal side effects of Ibuprofen vs Indomethacin for PDA closure

JORGE PISAPIA; LEONARDO GIUNTA; ALONSO MARÍA ROSARIO

BMJ PUBLISHING GROUP LONDRES

BMJ

Lugar: UK; Año: 2006 vol. 88 p. 1134 - 1135

Several studies showes the equivalence of both drugs por PDA closure in premature neonates. In addition ibuprofen was assosiates with less oliguria and less adverse renal side effects. As a result, iIbuprofen could be ussually recommended in neonates with pre existing oliguria