Influence of decarboxylation on Cannabis sativa’s antioxidant activity and flavonoid profile: A preliminary study

SAINT MARTIN, MALEN; MARRASSINI, CARLA; PERALTA, IGNACIO; COGOI, LAURA; ALONSO, MARÍA ROSARIO; ANESINI, CLAUDA

Medicinal Plant Communications

MS Editions

Lugar: Santiago de Chile; Año: 2023 vol. 52 p. 38 - 47

2452-4433

Cannabis sativa L. is used to treat drug-resistant epilepsy. Cannabinoids and phenolic compounds were identified in its composition. It is known that decarboxylation transforms acid cannabinoids into their neutral, usually more active, forms. Our aim was to determine the effect of the decarboxylation on C. sativa´s resin (CSR) antioxidant effect and its relationship with cannabinoids and polyphenolic compounds. The DPPH scavenger activity, the inhibition of lipid peroxidation and the metal chelating activities were determined for the raw CSR and decarboxylated C. sativa´s resin (CSRD). The phytochemical composition was studied by HPLC. The decarboxylation process modified the HPLC flavonoids profile and increased the resin’s antioxidant activities. The EC50 of CSRD for DPPH activity was 2.5 times lower than CSR EC50 (p