Vicenin-2 and vitexin participate in the in vitromodulation of the anti-inflammatory and antioxidant activities exerted by two Urtica circularis extracts

MARRASSINI, CARLA; SAINT MARTIN, ELINA MALEN; ALONSO, MARIA ROSARIO; ANESINI, CLAUDIA

BOLETíN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMáTICAS

SOC FITOQUIMICA LATINOAMERICANA

Año: 2023 vol. 23 p. 48 - 58

0717-7917

Abstract:Urtica circularisis an Argentinean species traditionally used to treat inflammation symptoms and oxidative stress-related diseases. Considering the uses in folk medicine, the purpose of this work was to evaluate and compare the anti-inflammatory and antioxidant activities of two different U. circularisextracts. The contribution of vicenin-2 and vitexin, two compounds identified in the phytochemical analysis, in the biological activity of the extracts was evaluated. The anti-inflammatory activity of the extracts and the isolated compounds was tested on lipopolysaccharide (LPS)-stimulated macrophages, while the antioxidant activity was evaluated through the 2,2 ́ diphenyl-1-picrylhydrazyl (DPPH) radical and 2,2 ́-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) diammonium salt (ABTS) scavenging activities. The popular uses of both extracts were validated, i.e., the use of U. circularisethanol extract for the treatment of inflammation, and the use of the aqueous extract to treat oxidative stress related-diseases. The differences in the biological activities observed between the extracts are probably due to qualitative and/or quantitative differences in the chemical composition and/or the occurrence of synergism between compounds