IPCSH - CENPAT 25618
INSTITUTO PATAGONICO DE CIENCIAS SOCIALES Y HUMANAS "DRA. MARÍA FLORENCIA DEL CASTILLO BERNAL"
Unidad Ejecutora - UE
artículos
Título:
Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair
Autor/es:
ZHU, GU; ADHIKARI, KAUSTUBH; HAMER, MEREL A.; ACUNA-ALONZO, VICTOR; GALLO, CARLA; BORTOLINI, MARIA CATIRA; XU, SHUHUA; ARFAN IKRAM, M.; WALSH, SUSAN; RUIZ-LINARES, ANDRÉS; MEDLAND, SARAH E.; LIU, FAN; HYSI, PIRRO G.; BRESLIN, KRYSTAL; PENG, FUDUAN; CANIZALES-QUINTEROS, SAMUEL; POLETTI, GIOVANNI; GONZALEZ-JOSE, ROLANDO; JIN, LI; CHEN, YAN; VAN DUIJN, CORNELIA M.; BRANICKI, WOJCIECH; WU, SIJIE; SPECTOR, TIMOTHY D.; PO?PIECH, EWELINA; KAYSER, MANFRED; MURALIDHARAN, CHARANYA; BEDOYA, GABRIEL; ROTHHAMMER, FRANCISCO; ZENG, CHANGQING; UITTERLINDEN, ANDRÉ G.; NIJSTEN, TAMAR; WANG, SIJIA; MARTIN, NICHOLAS G.
Revista:
HUMAN MOLECULAR GENETICS
Editorial:
OXFORD UNIV PRESS
Referencias:
Año: 2018 vol. 27 p. 559 - 575
ISSN:
0964-6906
Resumen:
Shape variation of human head hair shows striking variation within and between human populations, while its genetic basis is far from being understood. We performed a series of genome-wide association studies (GWASs) and replication studies in a total of 28 964 subjects from 9 cohorts from multiple geographic origins. A meta-analysis of three European GWASs identified 8 novel loci (1p36.23 ERRFI1/SLC45A1, 1p36.22 PEX14, 1p36.13 PADI3, 2p13.3 TGFA, 11p14.1 LGR4, 12q13.13 HOXC13, 17q21.2 KRTAP, and 20q13.33 PTK6), and confirmed 4 previously known ones (1q21.3 TCHH/TCHHL1/LCE3E, 2q35 WNT10A, 4q21.21 FRAS1, and 10p14 LINC00708/GATA3), all showing genome-wide significant association with hair shape (P
