PERSONAL DE APOYO
BEDECARRAS Patricia Gladys
artículos
Título:
AMH/MIS: what we know already about the gene, the protein and its regulation.
Autor/es:
REY, RA; LUKAS-CROISIER, C; LASALA, C; BEDECARRÁS, P
Revista:
MOLECULAR AND CELLULAR ENDOCRINOLOGY.
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Amsterdam; Año: 2003 vol. 211 p. 21 - 31
ISSN:
0303-7207
Resumen:
(AMH/MIS) was first suggested by Jost, more than Four decades before this gonadalglycoprotein was purified and its gene and promoter sequenced. In mammals, AMHexpression is triggered by SOX9 in Sertoli cells at the onset of testiculardifferentiation, and regulated by SF1, GATA factors, WT1, DAX1 and FSH. Ovariangranulosa cells also secrete AMH from late foetal life. In males, AMH is secretedinto the bloodstream at high levels until puberty when it is down-regulated byandrogens and meiotic germ cells and its directional secretion switches from the basal compartment to the seminiferous tubule lumen. In birds and reptiles, AMHexpression shows particular features. Serum AMH determination is useful to study testicular function in boys and in patients with gonadal tumours. AMH levels inseminal and follicular fluid may also be of clinical use.
