Procesamiento de las señales corporales en la Esclerosis Múltiple

INDIRA GARCÍA-CORDERO; DIANA BRUNO; FEDERICO ADOLFI; AGUSTÍN IBÁÑEZ; PAULA SALAMONE; SOFÍA ABREVAYA; FÁTIMA PAGANI; EZEQUIEL MIKULAN; LUCAS SEDEÑO; SOL ESTEVES; VLADIMIRO SINAY; JUAN BLAS COUTO; ADOLFO M. GARCÍA

Mar del Plata

Congreso; 53º Congreso Argentino de Neurología.; 2016

Sociedad Neurológica Argentina

The Heart Evoked Potential (HEP) is a negative modulation between 200 and 500 ms.that is associated with the perception and attention of internal bodily signals (named interoception)1,2. Its main neural basis are the insular cortex, anterior cingulate cortex (ACC) and somatosensory cortex3,4. Interoception is related to emotional awareness as shown by its influence on socio-cognitive domains as theory of mind, among others5. Moreover, social cognition processes activate neural networks that involve interoceptive cortices like insula and ACC. Regarding Multiple Sclerosis (MS), although several studies have described atrophy in the insular cortex6 and alterations in theory of mind, none of them have assessed whether interoceptive processing is affected in patients, neither its potential impact in social cognitive domains. Our objectives were: (i) to evaluate the HEP modulations and its cortical correlates in patients with MS and healthy controls; (ii) to assess the possible association between HEP modulation and patients performance in a theory of mind task.