New polymersomes based on tri-block copolymer (pvbz-b-peg-b-pvbz) as drug delivery systems

CORTIZO M. SUSANA; LUCAS N. BESADA; ANA M. CORTIZO

Maresias, Sao Paulo

Congreso; 14° Congresso da Sociedade Latino Americana de Biomateriais, Orgãos Artificiais e Engenharia de Tecidos ? SLABO; 2017

SLABO

The specific delivery of the therapeutic constituents of a drug to an organ, a tissue, or unhealthy cells using carriers is one of the major challenges in therapeutic research.1 Synthetic amphiphilic polymers have been widely developed over the last decades in order to form self-assembled polymer vesicles (polymersomes) which mimic lipid vesicles (liposomes). Polymersomes are more stable, more robust, and less permeable than liposomes thanks to the high molecular weight of polymers.2 These nanostructures are currently studiedas a means of drug delivery for their ability to entrap hydrophobic molecules in the membrane and encapsulate hydrophilic ones in the inner aqueous compartment.3 One unifying rule for generating polymersomes in water is a phospholipid-like ratio of hydrophilic to total mass: f ? 35% ± 10%. Molecules with f >45% can be expected to form micelles, whereas molecules with f