Evaluation of a fumaric copolymer as risedronate transdermal delivery system

M. PASQUALONE; M.S. CORTIZO; H.A. ANDREETTA

Foz do Iguaçu

Congreso; 9° Congresso Latino-Americano de Orgãos Artificiais e Biomateriais; 2016

Synthesis of polymeric matrix orientated to the development of transdermal delivery systems (TDDS) have several considerations involved in their design such as the drug nature and the vehicle (the polymer) characteristics. TDDS allows reaching a sustained and constant level of the drug concentration during the time, avoiding gastrointestinal problems which are common as a consequence of oral administration.Transdermal drug delivery devices are mainly based in acrylic copolymers, which are commercial products marketed in United States and Europe. In this work, we present the synthesis, characterization and evaluation of the release profile of an osteogenic drug (Risedronate, RI) from a material synthesized in ourlaboratory and able of being obtained using national supplies. The material is based in a fumaric copolymer obtained by radical polymerization using microwave energy. Membranes were elaborated with thiscopolymer using the solvent casting method, deposited on polyvinyl alcohol films. Their appearance was evaluated by optical microscopy and the morphologic properties were characterized by Scanning Electron Microscope (SEM). The drug delivery assays were performed in two RI/copolymer ratios (6 and 12% w/w),using a dissolution tester ELECTROLAB TDT 08L in phosphate buffer (pH =7.45) under constant agitation (100 rpm) at 34?C (n=3). The kinetic study was carried out by High Performance Liquid Chromatography (HPLC) in a HP 1100 chromatograph apparatus, equipped with a ZOBAX Eclipse XDB-C18 column (4,6 x 150 mm, 5 ?m), at 25°C , with diode array detector, settled at 262 nm (wavelength of maximum absorption of sodic RI), using as mobile phase a mixture of Phosphate Buffer : Methanol 75:25. The injection volume was 100 ?l. Drug release profiles of risedronate were analyzed using theoretical models, in order to study thedrug transport mechanism through the polymeric matrix.