Serology and longevity of immunity against echinococcus granulosus in sheep and llama induced by an oil based eg95 vaccine

THELMA VERONICA POGGIO; JENSEN OSCAR; MAFALDA MOSSELLO; JUAN JAVIER SERAFINO; DAVID HEATH

PARASITE IMMUNOLOGY

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2016 vol. 38 p. 496 - 502

0141-9838

An oil-based formulation of the EG95 vaccine to protectgrazing animals against infection with Echinococcus granu-losus was formulated in Argentina. The efficacy of the vaccinewas monitored by serology in sheep and llama (Lamaglama) and was compared to the serology in sheep previouslypublished using a QuilA-adjuvanted vaccine. Longtermefficacy was also tested in sheep by challenging withE. granulosus eggs of the G1 strain 4 years after the beginningof the trial. The serological results for both sheep andllama were similar to those described previously, except thatthere was a more rapid response after the first vaccination.A third vaccination given after 1 year resulted in a transientboost in serology that lasted for about 12 months, whichwas similar to results previously described. Sheep challengedafter 4 years with three vaccinations presented 842% reductionof live cysts counts compared with control group, andafter a fourth vaccination prior to challenge, this reductionwas 947%. The oil-based vaccine appeared to be bio-equivalentto the QuilA vaccine.