Overexpression of thioredoxins after antihypertensive pharmacological treatments is dissociated from cardiac hypertrophy inhibition and restored contractility in hypertensive rats

GÓMEZ LLAMBÍ H; M DONATO; B BUCHHOLZ; G CAO; G OTTAVIANO; MULLER A; GELPI R; M OTERO LOSADA; MILEI J

Congreso; 25 th European Meeting on Hypertension and Cardiovascular Protection,; 2015

Treatment with L, H and Cprevented the development of LVH. Losartan normalized the contractile responseto isoproterenol in SHR. Development of LVH with decline in the inotropicresponse to beta-adrenergic stimulation in hypertension may involve additionalfactors as well. High expression of thioredoxins observed afterantihypertensive treatments suggests a subsidiary benefit by enhancingantioxidant defense against oxidative stress in hypertension.on Hypertension andCardiovascular Protection, june 12-15, 2015, Milan, Italia.