PERSONAL DE APOYO
OTTAVIANO Graciela Mabel
congresos y reuniones científicas
Título:
Left ventricular remodeling in SHR
Autor/es:
SUAREZ D; G OTTAVIANO; N PAGLIA; J MILEI; GOMEZ LLAMBI H
Lugar:
La Plata
Reunión:
Congreso; XV Congreso Argentino de Hipertensión Arterial; 2008
Institución organizadora:
Sociedad Artentina de Hipertensión Arterial
Resumen:
The relationship between left ventricular hypertrophy
(LVH) and blood pressure (BP) has been described. In this sense male rats ,
eigth weeks old , from a group of Wistar (W)(n=22) , Wistar Kioto (WKY)(n=15)
and SHR (n=57) were studied. The SHR group was divided in a)SHR1
(BP<130)(n=10) and b)SHR2 (PS>130)(n=47). Ecocardiography and
systolic BP (SBP) (tail cuff method) in awake animals were recorded.
Ecocardiographic determinations including left ventricular mass (VM) and
relative thickness (RT) were obtained. Results: The body weigth (BW) in gr in W
was 316±13 ( p<0.05) vs. WKY 259±6.07 vs. SHR1 273±6.33 and vs. SHR2
274±3.6. The
SBP(mmHg) was in SHR2 (144±1.9)(p<0.05) vs. SHR1 121.7±2.2, vs WKY 113.7±3.66, and vs W
122.5±2.39. The
ecocardiographic determination showed an increment in septal and posterior wall
thickness and a reduction in dyastolic diameter in both SHR groups.The
VM/BW was similar in the four groups .On the other hand RT,
shows a significant differences between groups (W: 0.34±0.01 vs WKY 0.44±0.02 vs SHR2
0.52±.01
vs SHR1 0.55±0.02). The left ventricular contractile function did not show any significant
difference between groups. Conclusions: The developement of left ventricular
hypertrophy and remodeling could progress independtly of blood pressure
increment suggesting either genetic or hormonal factors.