Magnetic 3D scaffolds for tissue engineering applications: bioactive glass (45S5) coated with iron-loaded hydroxyapatite nanoparticles

DITTLER, MARÍA LAURA; ZELÍS, PEDRO MENDOZA; BELTRÁN, ANA M; DESTCH, RAINER; GRILLO, CLAUDIA A; GONZALEZ, MÓNICA C; BOCCACCINI, ALDO R

BIOMEDICAL MATERIALS

IOP PUBLISHING LTD

Año: 2021 vol. 16

1748-6041

Magnetic 45S5 bioactive glass (BG) based scaffolds covered with iron-loaded hydroxyapatite(Fe-HA-BG) nanoparticles were obtained and its cytotoxicity investigated. Fe-HA nanoparticleswere synthesized by a wet chemical method involving the simultaneous addition of Fe2+/Fe3+ ions.BG based scaffolds were prepared by the foam replica procedure and covered with Fe-HA bydip-coating. Fe-HA-BG magnetic saturation values of 0.049 emu g−1 and a very low remanentmagnetization of 0.01 emu g−1 were observed. The mineralization assay in simulated body fluidfollowing Kokubo?s protocol indicated that Fe-HA-BG scaffolds exhibited improved hydroxyapatiteformation in comparison to uncoated scaffolds at shorter immersion times. The biocompatibilityof the material in vitro was assessed using human osteoblast-like MG-63 cell cultures and mousebone marrow-derived stroma cell line ST-2. Overall, the results herein discussed suggest thatmagnetic Fe-HA coatings seem to enhance the biological performance of 45S5 BG based scaffolds.Thus, this magnetic Fe-HA coated scaffold is an interesting system for bone tissue engineeringapplications and warrant further investigation.