PERSONAL DE APOYO
GRILLO Claudia Alejandra
artículos
Título:
DNA-protein cross-links and sister chromatid exchanges induced by dimethylarsinic acid in human fibroblasts cells
Autor/es:
S.A. MOURÓN, C.A. GRILLO, F.N. DULOUT AND C.D. GOLIJOW
Revista:
MUTATION RESEARCH. GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2005 vol. 581 p. 83 - 90
ISSN:
1383-5718
Resumen:
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Biotransformation of inorganic arsenic to form both methylarsinic acid (MA) and dimethylarsinic acid (DMA) has traditionally been considered as a mechanism to facilitate the detoxification and excretion of arsenic. However, the methylation of inorganic arsenic as a detoxification mechanism has been questioned due to recent studies revealing an important role of organic arsenic in the induction of genetic damage. In a previous report a reduction of DNA migration after treatment of cells with DMA was described. In order to further evaluate the possible induction of protein?DNA adducts, an experiment was performed taking into account other parameters and modifications of the standard alkaline comet assay. In addition, the results obtained with the comet assay were compared with those obtained by analyzing the induction of sister chromatid exchanges (SCEs). SCE frequencies were significantly increased in treated cells in relation to controls (p < 0.001). Furthermore, in the standard alkaline comet assay, as well as in the control assay for proteinase K treatment, a significant dose-dependent reduction in tail moment was observed. Nevertheless, the post-treatment with proteinase K induced the release of proteins joined to the DNA and consequently, a dose-dependent increment in DNA migration was observed (p < 0.001). These results suggest that DNA?protein cross-links may be an important genotoxic effect induced by dimethylarsinic acid in human MRC-5 cells.
