CONICET | Buscador de Institutos y Recursos Humanos

This work focuses on the possible use of phenanthro [9,10-c]-1,2,5-thiadiazole 1,1-dioxide (TDZ) as a harmless corrosion inhibitor. With this purpose the TDZ range-dose to guarantee minimum adverse effects to the environment and to human health with satisfactory corrosion inhibition properties was evaluated. Cytotoxity and genotoxicity of TDZ in the concentration range 0.57-12.50 mM were tested using neutral red, chromosomal aberrations, mitotic index and colony formation. The results showed a significant increase of chromatid-type aberrations for the highest concentration of TDZ assayed (12.50 µM). Additionally, a reduction in proliferative rate for lower concentrations was detected through MI assay. Consequently, TDZ should be used taking into account that concentrations higher than 1.16 µM should be avoided. Fortunately, the corrosion assays performed in this investigation showed that good inhibition efficiency (ca. 50%) could be obtained with a low (0.65 µM) TDZ concentration. Consequently, the results showed that TDZ induced a time- and dose-dependent genotoxic and cytotoxic response, at least in CHO-K1 cells. They also indicate that short tests must be complemented with long exposure tests to simulate chronic contact to TDZ, because lower threshold levels may be found for the shorter exposures and a wrong safety range could be defined.

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