Parameter estimation to study the immediate impact of aortic cross-clamping using reduced order models

VENTRE, JEANNE; ARTHUR GHIGO; ARMENTANO R; LAGRÉE PY; TERESA POLITI; GAUDRIC J; CAPURRO CLAUDIA; JUAN FERNADEZ; KHELIFA I; JOSE-MARIA FULLANA

International Journal for Numerical Methods in Biomedical Engineering

John Wiley & Sons Ltd

Año: 2019

2040-7939

Aortic cross-clamping is a common strategy during vascular surgery, however,its instantaneous impact on hemodynamics is unknown. We, therefore,developed two numerical models to estimate the immediate impactof aortic clamping on the vascular properties. To assess the validity ofthe models, we recorded continuous invasive pressure signals during abdominalaneurysm repair surgery, immediately before and after clamping.The first model is a zero-dimensional (0D) three-element Windkesselmodel which we coupled to a gradient-based parameter estimation algorithmto identify patient-specific parameters such as vascular resistanceand compliance. We found a 10% increase in the total resistance and a20% decrease in the total compliance after clamping. The second modelis a 9-artery network corresponding to an average human body in whichwe solved the one-dimensional (1D) blood flow equations. With a similarparameter estimation method and using the results from the 0D model,we identified the resistance boundary conditions of the 1D network. Determiningthe patient-specific total resistance and the distribution of peripheralresistances through the parameter estimation process was sufficientfor the 1D model to accurately reproduce the impact of clamping onthe pressure waveform. Both models gave an accurate description of thepressure wave and had a high correlation (R? > 0.95) with experimentalblood pressure data.