Increased Expression of Aquaporin 9 in Trophoblast From Gestational Diabetic Patients.

PÉREZ-PÉREZ, ANTONIO; GUADIX P; DAMIANO, ALICIA E; VILARIÑO-GARCÍA, T; FERNÁNDEZ-SÁNCHEZ M; VARONE, CECILIA L; DIETRICH VALERIA; DUEÑAS JL; SÁNCHEZ-MARGALET VICTOR

HORMONE AND METABOLIC RESEARCH

GEORG THIEME VERLAG KG

Lugar: Stuttgart; Año: 2016

0018-5043

Gestational diabetes mellitus is the most frequent pathophysiological alteration in pregnancy, increasing the incidence of complications in both mother and fetus. The macrosomia that occurs in these fetuses may be related with some changes in nutrient transport mechanism in placenta. The presence of aquaporin 9, an aquaglyceroporin, has previously been demonstrated in placenta. We raised the question whether aquaporin 9 expression may be upregulated in placenta from gestational diabetes, thus providing a faster transport of glycerol and water through placenta. We studied 21 placentas (13 controls and 8 gestational diabetes) from cesarean delivery at term. The expression of aquaporin 9 was analyzed by quantitative PCR, immunoblot, and immunohistochemistry. The median values from quantitative PCR were compared by nonparametric tests for independent samples (Mann-Whitney U-test). We have found that trophoblast from gestational diabetes express higher amount of aquaporin 9, which was found statistically significant (p