Estrone: similar effects on vascular and bone tissues; ¿Risk or benefit?

RAUSCHEMBERGER M. BELÉN; MASSHEIMER VIRGINIA; CRESCITELLI MARÍA CARLA

MAR DEL PLATA

Congreso; LXIV Reunión Anual de la SAIC; 2019

SAIC

Estrogens play an important role in aterogenesis and bone remodelling. It is known that the decrease in estrogen levels during menopause negatively impacts on bone tissue and vascular function. We previously reported the osteoblastogenic effect of estrone (E1). Although the estrogen showed a positive action on bone tissue, we have also found negative effects tending to vascular lesion progression, whose most advanced stage involves vascular calcification. The aim of this work was to compare E1 effect on murine calvarial osteoblasts (OB) and vascular smooth muscular cells transdifferentiated into osteoblasts (CMLV-OB), particularly in modulation of cell maturation. E1 increased cell proliferation on both cellular types (39%, 27% above each/C p