Plasmodium sporozoite molecular cell biology.

KAPPE, S. H.; CARLOS ANDRES BUSCAGLIA; NUSSENZWEIG, V.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY

Año: 2004 vol. 20 p. 29 - 59

1081-0706

Plasmodium sporozoites display complex phenotypes including gliding motility, invasion of and transmigration through cells in the mosquito vector and the vertebrate host. Sporozoite studies have been difficult to perform because of technical concerns. However, they have already provided insights into several aspects of sporozoite biology, shared in part with other apicomplexan invasive stages. Structure/function analysis of the thrombospondin-related anonymous protein paved the way to the understanding of the molecular mechanisms of apicomplexan gliding motility and host cell invasion. Functional studies of circumsporozoite protein revealed its role in Plasmodium sporozoite morphogenesis in addition to its well-known function in host cell invasion. Transcriptional surveys are now facilitating the investigation of gene expression programs that control sporozoite phenotypes, revealing a high degree of previously unappreciated complexity and novel proteins mediating sporozoite host cell infection.