El ajo inhibe la migración y la proliferación de células aòrticas de ratas genéticamente hipertensas

GIL LORENZO ANDREA; CASTRO CLAUDIA; CRUZADO MONTSERRAT

Córdoba

Congreso; Primera Reunión Conjunta de Sociedades de Biología de la República Argentina XVI Jornadas Científicas de la Sociedad de Biología de Córdoba, IX Jornadas de la Sociedad Argentina de Biología y XXV Reunión Anual de la Sociedad de Biología de Cuyo con la par; 2007

Smooth muscle cell (SMC) proliferation and migration into the vascular wall are important processes of the vascular remodeling associated with hypertension. Garlic is widely recognized as a functional foodstuff that possesses a variety of beneficial effects on cardiovascular disease. In this study we investigated the effect of two organosulfur compounds derived from garlic, Allyl methyl sulfide (AMS, 2x10-5 and 10-4M) and Diallyl sulfide (DAS, 2x10-5 and 10-4M) on cultured aortic SMC from spontaneously hypertensive rats (SHR). 24 hours after AMS or DAS was added to aortic SMC, we evaluated both angiotensin II(AII)-stimulated migration by scrape-wound assay and fetal bovine serum (FBS)-stimulated proliferation by 3H-thymidine incorporation. Data (mean±SEM) presented as percent of control (AII or FBS alone), were analyzed by ANOVA and post test of Newman-Keuls. *P