Estrategias Biotecnológicas para el control de efermedades que afectan al ganado lechero, TBB y PTB

ROMANO M.I.; CATALDI A.; BIGI F.; TABOGA O.; CALAMANTE G.; GIOFFRE A.; MON M.L.; VIALE M.; BLANCO F.; BIANCO V.; DEL MEDICO ZAJAK M.P.; ZANETTI F.; LOPEZ M.G.; MOLINARI P.; BRIHUEGA B.; LA TORRE J.; SEKI C.; RUSPI D.; ARGENTO E.; ARGNTO O.; BERNARDELLI A.; BARCOS O.; GIMENEZ P.; FERNANDEZ SALUSTIO J; GARCIA SOLA M.; GARCIA SOLA G.

2011-03-01

2015-03-01

Biológica

Sanidad animal-Enfer. infec. bacterianas

>The goal of this project is to develop and validate novel and improved tools to contribute to the control of cattle diseases, which are either prevalent in Argentine or/and are naturally transmitted to human been (zoonoses). The Specific Aims are the following: 1) Improve and assess candidate vaccine, based on life attenuated strains; to protect animals against infection with Mycobacterium bovis and Mycobacterium avium paratuberculosis, the agents of tuberculosis (TB) and paratuberculosis (PTB), respectively. 2) Develop of novel non-living vaccines that are efficacious in prime-boost vaccination strategies against TB and PTB. 3) Develop a complementary diagnostic assay based on the detection of INF-g in blood samples to differentiate TB and PTB infected from vaccinated animals (DIVAs). 4) Validate and improved a Multiple Antigen Print Immunoassay (MAPIA) to assist the diagnosis of brucellosis, paratuberculosis, leptospirosis and neosporosis in cattle.