In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species

LAURELLA L; FRANK FM, (PRIMERA AUTORIA COMPARTIDA); SARQUIZ A; ALONSO MR; GIBERTI G; CAVALLARO L; CATALAN CA; CAZORLA SI; MALCHIODI EL; MARTINO VS; SULSEN VP

SCIENTIFIC WORLD JOURNAL, THE

THESCIENTIFICWORLD LTD

Lugar: New York; Año: 2012 vol. 1 p. 1 - 1

1537-744X

The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes, and dengue virus type 2. The organic extract of M. micrantha was the most active against T. cruzi and L. braziliensis exhibiting a growth inhibition of 77.6 ± 4.5% and 84.9 ± 6.1%, respectively, at a concentration of 10 μg/ml. The bioguided fractionation of M. micrantha organic extract led to the identification of two active fractions. The chromatographic profile and infrared analysis of these fractions revealed the presence of sesquiterpene lactones. None of the tested extracts were active against dengue virus type 2.