INVESTIGADORES
IMPERIALE Fernanda Andrea
artículos
Título:
Disposition of doramectin milk residues in lactating dairy sheep
Autor/es:
IMPERIALE, F.; MOTTIER, L; SALLOVITZ, J.; LIFSCHITZ, A.; LANUSSE, C.
Revista:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Editorial:
Ed. American Chemical Society Member
Referencias:
Lugar: Columbus, OH, USA; Año: 2003 vol. 51 p. 3185 - 3190
ISSN:
0021-8561
Resumen:
Doramectin (DRM) is a broad spectrum macrocyclic lactone antiparasitic drug not approved for use
in dairy animals. However, DRM and other endectocide compounds are widely used extra-label to
control endo- and ectoparasites in dairy sheep. The plasma disposition kinetics and the pattern of
DRM excretion in milk were characterized following its subcutaneous administration to lactating dairy
sheep. DRM concentration profiles were measured in plasma and milk samples after validation of a
specific HPLC-based methodology. DRM was detected between 1 h and 30 days post-treatment.
DRM concentrations of 0.48 ngâmL-1 (plasma) and 1.03 ngâmL-1 (milk) were measured at 30 days
post-treatment. DRM was extensively distributed from the bloodstream to the mammary gland, and
large concentrations were excreted in milk. The peak concentrations and total amount of DRM
recovered in milk (expressed as area under the concentration versus time curve) were 3-fold higher
than those measured in plasma; 2.44% of the total DRM dose was excreted in milk. The long
persistence of DRM milk residues should be seriously considered before its extra-label use in dairy
animals is recommended.
post-treatment. DRM was extensively distributed from the bloodstream to the mammary gland, and
large concentrations were excreted in milk. The peak concentrations and total amount of DRM
recovered in milk (expressed as area under the concentration versus time curve) were 3-fold higher
than those measured in plasma; 2.44% of the total DRM dose was excreted in milk. The long
persistence of DRM milk residues should be seriously considered before its extra-label use in dairy
animals is recommended.
post-treatment. DRM was extensively distributed from the bloodstream to the mammary gland, and
large concentrations were excreted in milk. The peak concentrations and total amount of DRM
recovered in milk (expressed as area under the concentration versus time curve) were 3-fold higher
than those measured in plasma; 2.44% of the total DRM dose was excreted in milk. The long
persistence of DRM milk residues should be seriously considered before its extra-label use in dairy
animals is recommended.
post-treatment. DRM was extensively distributed from the bloodstream to the mammary gland, and
large concentrations were excreted in milk. The peak concentrations and total amount of DRM
recovered in milk (expressed as area under the concentration versus time curve) were 3-fold higher
than those measured in plasma; 2.44% of the total DRM dose was excreted in milk. The long
persistence of DRM milk residues should be seriously considered before its extra-label use in dairy
animals is recommended.
post-treatment. DRM was extensively distributed from the bloodstream to the mammary gland, and
large concentrations were excreted in milk. The peak concentrations and total amount of DRM
recovered in milk (expressed as area under the concentration versus time curve) were 3-fold higher
than those measured in plasma; 2.44% of the total DRM dose was excreted in milk. The long
persistence of DRM milk residues should be seriously considered before its extra-label use in dairy
animals is recommended.
post-treatment. DRM was extensively distributed from the bloodstream to the mammary gland, and
large concentrations were excreted in milk. The peak concentrations and total amount of DRM
recovered in milk (expressed as area under the concentration versus time curve) were 3-fold higher
than those measured in plasma; 2.44% of the total DRM dose was excreted in milk. The long
persistence of DRM milk residues should be seriously considered before its extra-label use in dairy
animals is recommended.
âmL-1 (plasma) and 1.03 ngâmL-1 (milk) were measured at 30 days
post-treatment. DRM was extensively distributed from the bloodstream to the mammary gland, and
large concentrations were excreted in milk. The peak concentrations and total amount of DRM
recovered in milk (expressed as area under the concentration versus time curve) were 3-fold higher
than those measured in plasma; 2.44% of the total DRM dose was excreted in milk. The long
persistence of DRM milk residues should be seriously considered before its extra-label use in dairy
animals is recommended.