Analysis of the Interaction of serum albumin with titanium dioxide films using the extended Derjaguin-Landau-Verwey-Overbeek (X-DLVO) theory

MARIO R. ROSENBERGER; CARLOS E. SCHVEZOV; JONATHAN M. SCHUSTER

Phoenix, Arizona

Conferencia; TMS 2018 Annual Meeting & Exhibition; 2018

The Minerals, Metals & Materials Society

Abstract: Adhesion of serumalbumin is a key phenomenon to determine the degree of hemocompatibility of amaterial. Adhesion of a layer of albumin Will passivate the material surfaceavoiding blood clot formation and platelets activation and then define it as ahemocompatible material. Adhesion is strongly related to the free surfaceenergy and the interaction potentials between a material surface and thealbumin molecule in water. The X-DLVO theory is employed to calculate the vander Waals and acid base interaction potential for TiO2 nanofilms produced bythe sol-gel method, with an albumin molecule in water. The resultant value ofthe interaction potential for TiO2 was compared with the calculated valuesobtained applying the same theory, for pyrolytic carbon and 316L stainlesssteel. It was found that the acid-base potential was dominant in theinteraction potential for the three materials.