A Mild Procedure for Enone Preparation Catalysed by Bovine Serum Albumin in a Green and Easily Available Medium

ARDANAZ, SEBASTIÁN M.; VELEZ RUEDA, ANA J.; PARISI, GUSTAVO; IRIBARREN, ADOLFO M.; IGLESIAS, LUIS E.

CATALYSIS LETTERS

SPRINGER

Año: 2018 vol. 148 p. 1750 - 1757

1011-372X

A simple and mild procedure to obtain α,β-unsaturated ketones from acetone and a set of benzaldehydes is described. Theapproach applies bovine serum albumin (BSA) catalysis and water or ethanol, this mild reaction medium contrasting withthe strong reaction conditions of the classic aldol condensation. Except for the assayed nitrobenzaldehydes, high enoneyields (88?97%) were attained. In addition to its mildness, further advantages of this procedure are the use of a green catalystexhibiting an efficient reuse and the use of eco-friendly and cheap solvents. In order to gain a deeper understanding of theinvolved catalytic mechanism, computational experiments on BSA structural analysis and molecular docking were carried out.