Deciphering heme oxygenase-1 role in head and neck cancer

MASCARÓ E,; GANDINI, NA; ALONSO, EN; COLÓ, GP; RABASSA, M; ABBA,M; PICHEL, P; RECIO, S; FERMENTO, ME; GUEVARA JA; FACCHINETTI, MM; CURINO, AC

Mar del Plata

Congreso; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIA 2018; 2018

Sociedad Argentina de Investigación Clínica

Head and neck squamous cell carcinoma (HNSCC) is a remarkably heterogeneous disease due to phenotypic, aetiological, biological andclinical characteristics with around 50% mortality, which has propelled research for new approaches to improve patient survival. Wepreviously reported that heme oxygenase-1 (HO-1) protein is up-regulated in human HNSCC samples and that it is localized in thecytoplasmic and nuclear compartments; additionally, we demonstrated that HO-1 nuclear localization is associated with malignantprogression.In this study, we aim 1) to further evaluate the prognostic utility of HO-1 expression as well as 2) to begin to elucidate which role does HO-1 play in HNSCC pathophysiology.