Mononegaviruses of Veterinary Importance Vol. II. CHAPTER 9

MARINA MOZGOVOJ; MARIA JOSE DUS SANTOS

CABI

Año: 2016 p. 376

978-1780641799

Bovine respiratory syncytial virus (bRSV) is the main cause of respiratory disease in beef and dairy cattle worldwide. It is responsible for substancial economic losses to the livestock industry due to morbidity, mortality, treatment and prevention costs. Several studies have demonstrated that the frequency of bRSV infection is correlated to the density of the cattle population and the age of the animals. The virus has been isolated in several countries including Europe, America and Asia. Seroprevalence studies have also shown that bRSV is widely distributed in many countries, regardeless of the geographical location, INDICATING that viral transmission is common among herds. Limited information is available about molecular epidemiology of the virus. DNA sequencing and phylogenetic analysis have hugely contributed to define bRSV genotypes, evolution, spread and transmission, however, future studies analyzing longer sequence of bRSV should be performed in order to provide more accurate information about circulating strains. bRSV outbreaks often occur during winter but they have been also reported during summer. Animals can be infected even with the same strain several times through life, for that reason, it is important to update epidemiology studies in order to design more effective control strategies.There are multiple vaccines available in the market for bRSV, however, their efficacy is controversial. An ideal vaccine should be efficacious in the presence of maternal antibodies and should be able to induce a long-lasting protective immune response. Although significant progress has been made with regards to prevention measures, additional insights should be done to better identify prophylactic and therapeutic compounds. bRSV control should be understand as linkage between profilatic measures, such a efficacious vaccines, cattle management and ......(los tres engranajes de la tesis de andre)These three issues have not to be consider as individual factors involved in bRSV infection, but as a motor gear with all its parts working together