INVESTIGADORES
BALDONI Hector Armando
artículos
Título:
New antitumoral acetogenin "Guanacone type" derivatives: Isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone
Autor/es:
BARRACHINA, I.; ROYO, I.; BALDONI, H. A.; CHAHBOUNE, N.; SUVIRE, F.; DEPEDRO, N., ZAFRA-POLO, M.C., BERMEJO, A., EL AOUAD, N., CABEDO, N., SAEZ, J., TORMO, J.R., ENRIZ, R.D. AND CORTES, D.
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2007 vol. 15 p. 4369 - 4381
ISSN:
0968-0896
Resumen:
We describe herein the isolation and semisynthesis of four acetogenin derivatives (1-4) as well as their ability to inhibit the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound 4, in a fully hydrated POPC bilayer, is reported.
