INVESTIGADORES
DI CHENNA Pablo Hector
artículos
Título:
Late-stage C–H amination of abietane diterpenoids
Autor/es:
LAPUH, MARÍA IVANA; DANA, ALEJANDRO; DI CHENNA, PABLO H.; DARSES, BENJAMIN; DURÁN, FERNANDO J.; DAUBAN, PHILIPPE
Revista:
ORGANIC & BIOMOLECULAR CHEMISTRY
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Año: 2019
ISSN:
1477-0520
Resumen:
This study aims at highlighting the synthetic versatility of the rhodium-catalyzed C?H amination reactions using iodine(III) oxidants for the late-stage functionalization of natural products. Inter- and intramolecular nitrene insertions have been performed from various abietane diterpenoids, leading to the amination of the C-3, C-6, C-7, C-11 and C-15 positions. Ca. 20 aminated compounds have been isolated with yields of up to 86% and high levels of regio-, chemo- and stereoselectivities.
