INVESTIGADORES
DI CHENNA Pablo Hector
artículos
Título:
Synthesis of C(1)-C(11) oxygen-bridged pregnanes
Autor/es:
VELEIRO, ADRIANA S.; TAICH, P. J.; ALVAREZ, L.; DI CHENNA PABLO H.; BURTON, GERARDO
Revista:
TETRAHEDRON LETTERS
Editorial:
Elsevier
Referencias:
Año: 2005 vol. 46 p. 4235 - 4238
ISSN:
0040-4039
Resumen:
AbstractA general procedure for the synthesis of 1a,11a- and 1b,11a-epoxysteroids is described, using an intramolecular remote
functionalization reaction involving the photolysis of 11a-hydroxysteroids in the presence of diacetoxyiodobenzene and iodine.
Three 1,11-epoxypregnanes were prepared, two of them (compounds 10 and 14) are conformationally constrained analogues of
steroidal hormones, compound 13 is a synthetic precursor of neurosteroids.A general procedure for the synthesis of 1a,11a- and 1b,11a-epoxysteroids is described, using an intramolecular remote
functionalization reaction involving the photolysis of 11a-hydroxysteroids in the presence of diacetoxyiodobenzene and iodine.
Three 1,11-epoxypregnanes were prepared, two of them (compounds 10 and 14) are conformationally constrained analogues of
steroidal hormones, compound 13 is a synthetic precursor of neurosteroids.a-hydroxysteroids in the presence of diacetoxyiodobenzene and iodine.
Three 1,11-epoxypregnanes were prepared, two of them (compounds 10 and 14) are conformationally constrained analogues of
steroidal hormones, compound 13 is a synthetic precursor of neurosteroids.10 and 14) are conformationally constrained analogues of
steroidal hormones, compound 13 is a synthetic precursor of neurosteroids.13 is a synthetic precursor of neurosteroids.
