Inducción de apoptosis por superantígenos en linfomas/leucemias B

DUARTE ALEJANDRA; BERGER PAULA; SIELECKI ALEJANDRO; ALEMAN MERCEDES; NEPOMASCHI IRENE; PIAZZÓN ISABEL

Buenos Aires

Jornada; Jornada. XXXI jornadas multidiciplinarias de oncologia del Instituto Roffo.; 2016

Superantigens (Sags) are bacterial and virus protein that share the ability to activate large number of T-cells. Sags bind to major histocompatibility complex (MHC) class II molecules as unprocessed proteins and interact with T cells expressing particular T-cell receptor (TCR) Vβ chains. Several Sags activated T-cells after several rounds of proliferation. Sag reactive T-cells undergo apoptosis. We previously demonstrated that T-cell Sags induced apoptosis of cognate malignant T cells. We have shown that bacterial- and mouse mammary tumour virus (MMTV)-encoded Sags are induce apoptosis of different murine-cognate lymphoma T cells both in vitro and in vivo, being the Fas/Fas-L pathway involved. In vivo exposure to bacterial T Sags increased the survival of lymphoma-bearing mice. We also observed that Sags induce apoptosis in cells of the Jurkat-established human cell line from an acute T-carrier leukemia of the Vβ8 region in TCR. We proposed analyze the mechanism involved in apoptosis activation of Sags on Jurkat cells.