INVESTIGADORES
COMERCI Diego Jose
artículos
Título:
Brucella alters the immune response in a prpA-dependent manner
Autor/es:
SPERA J. M; COMERCI D. J; UGALDE JE
Revista:
MICROBIAL PATHOGENESIS
Editorial:
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2014 p. 1 - 6
ISSN:
0882-4010
Resumen:
Brucellosis, a disease caused by the gram-negative bacterium Brucella spp., is a widespread zoonosis that
inflicts important animal and human health problems, especially in developing countries. One of the
hallmarks of Brucella infection is its capacity to establish a chronic infection, characteristic that depends
on a wide repertoire of virulence factors among which are immunomodulatory proteins such as PrpA
(encoding the proline racemase protein A or hydroxyproline-2-epimerase), involved in the establishment
of the chronic phase of the infectious process that we have previously identified and characterized. We
report here that, in vivo, Brucella abortus prpA is responsible for an increment in the B-cell number and in
the specific antibody response and that these antibodies promote cell infection. We additionally found
that Brucella alters the cytokine levels of IFN-g, IL-10, TGFb1 and TNFa during the acute phase of the
infectious process in a prpA dependent manner.