Evaluación de la eficacia protectiva de la vacuna antibrucélica experimental Brucella abortus Delta-pgm en bovinos

COMERCI D. J; REY SERANTES D.A.; CARBALLO E.; PARAMIDANI E.; BAGNAT E.; UGALDE JE

SNS

SENASA

Lugar: Buenos Aires; Año: 2013 vol. 1 p. 1 - 16

2314-2901

Bovine brucellosis is still a worldwide spread zoonosis that causes important economic losses and human health problems in many regions. Although there are several vaccine strains, each one of them has one or more disadvantages that can range from a poor protection capacity to interferences in the diagnostic methods that are currently used in routine control of the disease. For all these reasons, there is still a need for the development of novel vaccines with advantages over the currently available ones. In this paper we present the results of a vaccination-challenge study comparing the potency of the novel strain Delta-pgm with that of S-19, the vaccine that is being used in Argentina. Several parameters were analyzed on 32 animals inoculated with either of the two strains, or not vaccinated at all: serological titers during the complete experiment, bacteremia of the mothers analyzed by blood culture, gestation period, condition of the offspring at delivery (dead, alive, premature) and excretion of bacteria through milk. Our results indicate that that Delta-pgm administered in a two-dose regime (one before 6 months of age and a second one in adulthood) does not generate any serological interference with the current diagnostic methods and induces a protection that is similar to that induced by the S-19 strain. These results suggest that Delta-pgm could be a potential new tool for adult animals vaccination