INVESTIGADORES
MARTIN Valentina
artículos
Título:
Toxoplasma gondii Infection Induces Suppression in a Mouse Model of Allergic Airway Inflammation
Autor/es:
IGNACIO MARTÍN FENOY; ROMINA CHIURAZZI; VANESA ROXANA SÁNCHEZ; MARIANA ALEJANDRA ARGENZIANO; ARIADNA SOTO; MARIANO SERGIO PICCHIO; VALENTINA MARTIN; ALEJANDRA GOLDMAN
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2012 vol. 7 p. 1 - 11
ISSN:
1932-6203
Resumen:
Allergic asthma is an inflammatory disorder characterized by infiltration of the airway wall with inflammatory cells drivenmostly by activation of Th2-lymphocytes, eosinophils and mast cells. There is a link between increased allergy anda reduction of some infections in Western countries. Epidemiological data also show that respiratory allergy is less frequentin people exposed to orofecal and foodborne microbes such as Toxoplasma gondii. We previously showed that both acuteand chronic parasite T. gondii infection substantially blocked development of airway inflammation in adult BALB/c mice.Based on the high levels of IFN-c along with the reduction of Th2 phenotype, we hypothesized that the protective effectmight be related to the strong Th1 immune response elicited against the parasite. However, other mechanisms could alsobe implicated. The possibility that regulatory T cells inhibit allergic diseases has received growing support from both animaland human studies. Here we investigated the cellular mechanisms involved in T. gondii induced protection against allergy.Our results show for the first time that thoracic lymph node cells from mice sensitized during chronic T. gondii infectionhave suppressor activity. Suppression was detected both in vitro, on allergen specific T cell proliferation and in vivo, onallergic lung inflammation after adoptive transference from infected/sensitized mice to previously sensitized animals. Thisability was found to be contact- independent and correlated with high levels of TGF-b and CD4+FoxP3+ cells.