“17beta-estradiol signaling in skeletal muscle cells and its relationship to apoptosis”.

RICARDO BOLAND; ANDREA VASCONSUELO; LORENA MILANESI; RONDA, ANA C; ANA RUSSO DE BOLAND

STEROIDS

Año: 2008 vol. 73 p. 859 - 863

0039-128X

Abstract: 17b-estradiol exerts an antiapoptotic action in skeletal muscle cells through extranuclear ER a and b. This protective action, mainly involves a non-genomic mechanism of ERK1/2 and PI3K/Akt activation and BAD phosphorylation. ER b plays a major role in the inhibition of apoptosis by 17b-estradiol at the level of mitochondria, whereas ER a and ER b mediate the activation of Akt to the same extent, suggesting differential involvement of ER isoforms depending on the step of the apoptotic/survival pathway involved. The myopathies associated to estrogen deficit states may be related to the mechanisms by which estrogen regulates apoptosis.