1alpha,25(OH)2-vitamin D3 and 17beta-estradiol: two steroid partners acting in skeletal muscle.

BUITRAGO, CLAUDIA; MILANESI, LORENA; RONDA, ANA C; VASCONSUELO, ANDREA; BOLAND, RICARDO

Immun., Endoc. & Metab. Agents in Med. Chem.,

Bentham Science Publishers Ltd.

Año: 2009 vol. 9 p. 159 - 168

1568-0134

Abstract: 1a,25(OH)2-vitamin D3 and 17b-estradiol regulate skeletal muscle cell proliferation, differentiation, apoptosis and contractility through receptor-mediated transcriptional and non-genomic mechanisms. This review focuses on recent advances on signal transduction pathways activated by both steroid hormones. Data are given on the participation of the VDR and ERs (a  and b ) in activation of MAPKs in muscle cells. Likewise, we describe novel evidence supporting non-classical localizations of the VDR in the plasma membrane and ER b in mitochondria. 1 a ,25(OH)2D3 promotes DNA synthesis in skeletal muscle cells implicating c-Src/ERK1/2, whereas 17 b -estradiol inhibits apoptosis through ERK2 and p38 MAPKs. This study provides basis for the understanding of vitamin D- and estrogen-dependent myopathies.