INVESTIGADORES
LEVI Valeria
artículos
Título:
Retraction of rod-like mitochondria during microtubule-dependent transport
Autor/es:
DE ROSSI, M CECILIA; LEVI, VALERIA; BRUNO, LUCIANA
Revista:
BIOSCIENCE REPORTS
Editorial:
PORTLAND PRESS LTD
Referencias:
Lugar: Londres; Año: 2018
ISSN:
0144-8463
Resumen:
Molecular motors play relevant roles on the regulation of mitochondria size and shape, essentialproperties for the cell homeostasis. In this work, we tracked single rod-shaped mitochondria withnanometer precision to explore the performance of microtubule motor teams during processiveanterograde and retrograde transport. We analyzed simultaneously the organelle size and verifiedthat mitochondria retracted during retrograde transport with their leading tip moving slower incomparison to the rear tip. In contrast, mitochondria preserved their size during anterograde runsindicating a different performance of plus-end directed teams. These results were interpretedconsidering the different performance of dynein and kinesin teams and provide valuableinformation on the collective action of motors during mitochondria transport.
