Amplificación del proto-oncogén HER-2/neu asociada a la infección por VPH de bajo riesgo en muestras de citología exfoliativa cervical

ABBA MC; MOURÓN SA; GÜERCCI A; GÓMEZ MA; DULOUT FN; GOLIJOW CD

Revista Mexicana de Patología Clínica

Sociedad Mexicana de Patología Clínica

Lugar: Mexico; Año: 2000 vol. 1 p. 26 - 31

0185-6014

Sixty-nine non-cancerous cytological samples from exocervical specimens positives for HPV type-6, -16 and -18, and 24 noninfected samples as controls were analyzed for HER-2/neu gene amplification. The genomic differential polymerase chain reaction with the single copy reference gene was employed for gene amplification detection. An association between HER-2/neu gene amplification and ìlow-riskî HPV group (type-6) was found (p < 0.005). Within this group, HER2/neu amplification was associated to the CIN I grade (p < 0.01). Since, in the samples analyzed most of the CIN I stage was characterized by a koilocitotic pattern, HER-2/neu amplification could be related to this kind of cellular alteration. It would be important the study of HER-2/neu gene amplification and also gene expression in different CIN stages, in order to determine its role and significance in cervical carcinogenesis.