Parahydrogen Induced Polarization of Barbituric Acid Derivatives. 13C Hyperpolarization Studies.

M. ROTH; R. H. ACOSTA; J. BARGON; H.W. SPIESS; A. KOCH; K. MÜNNEMANN

Angra dos Reis, Brasil

Congreso; 12th Nuclear Magnetic Resonance Users Meeting & 3rd Iberoamerican NMR Meeting.; 2009

The application of 13C-NMR spectroscopy and imaging for clinical diagnostics hasbeen constrained by the extremely long imaging and spectroscopy acquisitiontimes that are required to obtain high SNR under physiological conditions.However, this obstacle could be overcome by in vitro hyperpolarization of a 13Ccontaining molecule with long spin lattice relaxation time via PHIP [1] andsubsequent injection into the animal or patient of investigation. Hence, the role ofcertain target compounds such as anesthetics could be investigated by using MRItechniques. Among the drugs used to treat epilepsy or for injection narcotics,barbiturates like 5-methyl-5-propargylbarbituric acid are attractive from the MRIand chemical point of view because of their long spin lattice relaxation time of thecarbons and the straightforward synthesis of model structures.