Combination of OPSY and PhD-PHIP results in enhanced sensitivity in PHIP

BUSSANDRI, S.; BULJUBASICH, L.; ACOSTA, R.H.

JOURNAL OF MAGNETIC RESONANCE

ACADEMIC PRESS INC ELSEVIER SCIENCE

Año: 2019 vol. 299 p. 28 - 32

1090-7807

Despite the large degree of polarization in PHIP experiments compared to the Boltzmann factor, the presenceof a large amount of non-reacted molecules with thermal polarization is an important obstaclewhen dealing with very diluted samples. The feasibility of enhancing both sensitivity and resolution ina single experiment by combining two well established pulse sequences, OPSY and PHD-PHIP is presented.OPSY is used as a block for filtering the signals originated from thermally polarized protons.PhD-PHIP, on the other hand, is used as an acquisition block, increasing the resolution and furtherimproving the sensitivity by preventing signal canceling in the presence of magnetic field inhomogeneities.Experiments in a complex sample with very low hyperpolarization levels are presented showingthe excellent performance of the method.