p300 involvement in the metastatic process of triple-negative breast cancer

GALLARDO GA; CLEMENTE V; MASCARÓ MARILINA; FACCHINETTI MM; CURINO AC; FERMENTO ME

Mar del Plata

Congreso; LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2019

Sociedad Argentina de Investigación Clínica (SAIC)

Triple negative breast cancer (TNBC) are a heterogeneous group of tumors which lack specific molecular targets. Therefore, it is necessary to investigate potential tumor markers for this subtype of BC. Recent studies indicate that p300 has a pro-metastatic role in BC and we have previously shown that inhibition of p300 decreases cellular migration and invasion in a TNBC cell line. Therefore, in this work we aimed to analyze the expression and localization of p300 and its association with markers of tumor progression and clinic-pathological parameters in human TNBC. Also, we investigated the molecular mechanisms through which p300 inhibition impaired the processes previously mentioned. In TNBC biopsies (n=45), we found that higher levels of cytoplasmic p300 correlates with lower tumor stages and a better overall patient survival (IHC, p