Antitumoral effects of Grifola frondosa (Maitake) D fraction in breast cancer.

CURINO A. C.; FERRONATO M.J.; GANDINI N.A.; OBIOL, D.J.; FERMENTO M.E.; FACCHINETTI M.M.; LOPEZ ROMERO A.; ALONSO E.N.

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Simposio; Third South American Symposium in Signal Transduction and Molecular Medicine (SISTAM2015); 2015

ANTITUMORAL EFFECTS OF GRIFOLA FRONDOSA (MAITAKE) D FRACTION IN BREAST CANCER.Curino, Alejandro C(1); Ferronato, María J(1); Gandini, Norberto A(1); Obiol, Diego J(1); Fermento, María E(1); Facchinetti, María M(1); López Romero, Alejandro(2); Alonso, Eliana N(1).(1) Laboratorio de Biología del Cáncer, INIBIBB-CONICET, Bahía Blanca, Argentina.(2) Laboratorio de Citometría ? IACA Laboratorios, Bahía Blanca, Argentina.acurino@criba.edu.ar ABSTRACTD Fraction is a proteoglycan extract obtained from the medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D Fraction is mainly attributed to its immunomodulatory capacity and numerous studies have investigated the cellular and molecular mechanisms involved in this capacity. Recently, some reports have described a direct effect of D fraction on some neoplastic cells. We propose to demonstrate that D Fraction is also able to act directly on mammary tumor cells MDA-MB-231 and LM3, modulating their tumoral capacities and to elucidate the molecular mechanisms involved. We observed that D Fraction treatment decrease cell viability of MDA-MB-231 and LM3 in a dose‐ and time‐dependent manner, compared to vehicle-treated cells (WST-1 and subsequent manual counting; p