Antitumoral effects of a novel Gemini Vitamin D analogue

FACCHINETTI M.M.; ALONSO, E.N.; OBIOL D.J.; GANDINI N.A.; FERMENTO M.E.; FALL Y. D.; CURINO A. C.; FERRONATO M.J.

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Simposio; Third South American Symposium in Signal Transduction and Molecular Medicine (SISTAM2015); 2015

ANTITUMORAL EFFECTS OF A NOVEL GEMINI VITAMIN D ANALOGUEFacchinetti MM1*, Alonso EN1, Obiol DJ1, Gandini NA1, Fermento ME1, Fall Y2, Curino AC1, Ferronato MJ11. Laboratorio de Biología del Cáncer- Instituto de Investigaciones Bioquímicas Bahía Blanca-Centro Científico Tecnológico Bahía Blanca, Argentina.2. Departamento de Química Orgánica, Facultad de Química, Universidad de Vigo, España.*facchinm@criba.edu.ar1α,25-dihydroxyvitamin D3 (calcitriol) shows potent growth-inhibitory properties on different cancer cell lines although its hypercalcemic effects have severely hampered its therapeutic application. Therefore, structural analogues are being designed and synthesized with the aim at finding one that exerts antitumor effects with lack of calcemic activity. In collaboration with the laboratory of Organic Chemistry of the University of Vigo we synthesized a novel Gemini analogue of calcitriol, called UVB1. The aim of this study was to evaluate the antitumor action of UVB1 on different cell lines, comparing its effects with those elicited by calcitriol, and investigate analogue effects on a colorectal carcinoma animal model. The results show that the analogue retards cell migration (p